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There was also a significant association between CA repeat length and diarrhea grade ≥ 2. CYP3A4 polymorphisms were marginally associated rash. People with low expression of CYP3A4 (A / A) were more likely to develop skin rash (46 [78%] of where can I purchase soma 200 mg Pittsburgh 59 patients) than those with high levels of CYP3A4 (eight [62%] of 13, a GS / and three [43%] of seven homozygotes G / G, p = 0.077).

Similarly, the CYP3A5 * 3 G polymorphism was also marginally associated with a rash of grade ≥ 2 (p = 0.094, dominant model) and a grade of diarrhea (p = 0.062, recessive model). Finally, patients in the category of diplotypes 2,3,4 / 2,3,4 had a rash rate of where can I purchase soma 200 mg Pittsburgh grade ≥ 2 as 3.4 1 / 1 or 1 / 2, the groups (p = 0.095 The recessive model). The relative frequency of a haplotype (AG, a lower expression of CYP3A) was slightly higher in patients with rash where can I purchase soma 200 mg Pittsburgh than those without rash (p = 0.089, data not shown) and significantly higher among people with all type of diarrhea annually, compared to those without diarrhea (P where can I purchase soma 200 mg Pittsburgh = 0.029, data not shown). A marginally significant association between ABCG2 16702 G / A polymorphism and any grade of skin toxicity (p = 0.089). G / G and A / A patients were more likely to develop toxicity (77% and 80% respectively) compared to the L / R (50%). A more coherent relationship is perceived by ≥ where can I purchase soma 200 mg Pittsburgh grade 2 rash, with genotype G / G have a higher rate of toxicity compared to the G / A or A polymorphisms where can I purchase soma 200 mg Pittsburgh / C in a model of dominance (p = 0.027).

A marginally significant association was detected between 15 622 C / T and all types of diarrhea grade (P = 0.066): 20 (41%) of 49 patients C / C developed diarrhea, compared with 20 of 31 ( 65%) C / T patients or T / T.

A multivariate logistic regression was performed to evaluate the effects of genetic polymorphisms on the toxicity control of PK (and vice versa). Because the Cmin was significantly associated with a rash of grade ≥ 2 (Table 2) and Cmin levels captured most of the associations between polymorphisms and PK (Table 3), this variable was chosen as pharmacokinetic parameters for the multivariate analysis. The results are presented in Table 5 for the eruption and Table 6 of where can I purchase soma 200 mg Pittsburgh diarrhea. Due to small numbers, multivariate analysis of diarrhea grade ≥ 2 was not performed. Higher levels of C min were associated withincreased risk of rash of grade ≥ 2, the likely increase in eruption about 1.8 times for every 1 mg / dL increase in the level of depression.